人结肠癌细胞

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人结肠癌细胞(SW620)

￥800.00元

细胞货号： CL0305

细胞种属： 人源细胞系

细胞别名： SW-620; SW 620; SW.620

发货规格： 1×10⁶

供体信息： 51岁白人男性

肿瘤类型： 结直肠腺癌

组织来源： 大肠

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背景信息

种属：人源细胞系
组织来源：大肠
肿瘤类型：结直肠腺癌
供体信息： 51岁白人男性
背景描述： SW-620细胞系来自一名患有Dukes-C型结直肠癌的51岁男性的大肠，是结直肠癌的关键研究模型，特别是用于癌症生物标志物、化疗和转移性癌细胞的研究。SW-620细胞是研究细胞凋亡和抗失巢凋亡机制的关键，失巢凋亡是一种对防止转移至关重要的程序性细胞死亡形式。利用SW-620结肠癌细胞的研究已经深入到蛋白质组分析中，以了解不同条件下（如缺氧）的蛋白质组变化。低氧SW620细胞表现出特定的蛋白质组适应，这有助于化疗耐药性。

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其他信息

蛋白表达： keratin
同工酶： ES-D, 1；G6PD, B；PEP-D, 1；PGD, A；PGM1, 2；PGM3, 1
基因表达： carcinoembryonic antigen (CEA) 0.15 ng/106 cells/10 days; transforming growth factor alpha; matrilysin; CSAp negative; and colon antigen 3 negative; keratin positive by immunoperoxidase staining; c-myc; K-ras; H-ras; N-ras; Myb; sis; fos
致癌基因： myc+; myb+; ras+; fos+; sis+; p53+; abl-; ros-; src-
致瘤性： Yes, in nude mice。(Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 10(7) cells)
抗原表达： Blood type A; Rh+
突变信息： There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution.The line is positive for expression of c-myc, K-ras, H-ras, N-ras, Myb, sis and fos oncogenes.
核型： modal number = 50; range = 45 to 53. The stemline chromosome number is hyperdiploid with the 2S component occurring at 12% and 11 marker chromosomes were common to S metaphases. One of the 11 markers [7 (7p; 11p)] was disomic., M1 was probably an HSR but the origin of the chromosome could not be identified.

人结肠癌细胞

Catalog No CL0305

Product information

蛋白表达： keratin
同工酶： ES-D, 1；G6PD, B；PEP-D, 1；PGD, A；PGM1, 2；PGM3, 1
基因表达： carcinoembryonic antigen (CEA) 0.15 ng/106 cells/10 days; transforming growth factor alpha; matrilysin; CSAp negative; and colon antigen 3 negative; keratin positive by immunoperoxidase staining; c-myc; K-ras; H-ras; N-ras; Myb; sis; fos
致癌基因： myc+; myb+; ras+; fos+; sis+; p53+; abl-; ros-; src-
致瘤性： Yes, in nude mice。(Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 10(7) cells)
抗原表达： Blood type A; Rh+
突变信息： There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution.The line is positive for expression of c-myc, K-ras, H-ras, N-ras, Myb, sis and fos oncogenes.
核型： modal number = 50; range = 45 to 53. The stemline chromosome number is hyperdiploid with the 2S component occurring at 12% and 11 marker chromosomes were common to S metaphases. One of the 11 markers [7 (7p; 11p)] was disomic., M1 was probably an HSR but the origin of the chromosome could not be identified.

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