储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1154R
特异性： Endogenous
基因名称： APC
蛋白名称： Adenomatous polyposis coli protein
别名： APC;DP2.5;Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5
Organism-1： Human
基因ID-1： 324
SwissProt-1： P25054
Organism-2： Mouse
SwissProt-2： Q61315
Organism-3： Rat
基因ID-3： 24205
SwissProt-3： P70478
背景： This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],
细胞定位： Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm . Cell membrane . Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1154R
特异性： Endogenous
基因名称： APC
蛋白名称： Adenomatous polyposis coli protein
别名： APC;DP2.5;Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5
Organism-1： Human
基因ID-1： 324
SwissProt-1： P25054
Organism-2： Mouse
SwissProt-2： Q61315
Organism-3： Rat
基因ID-3： 24205
SwissProt-3： P70478
背景： This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],
细胞定位： Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm . Cell membrane . Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
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