储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1138R
特异性： Endogenous
基因名称： DCLK1 DCAMKL1 DCDC3A KIAA0369
蛋白名称： DCLK1
Organism-1： Human
基因ID-1： 9201
SwissProt-1： O15075
Organism-2： Mouse
基因ID-2： 13175
SwissProt-2： Q9JLM8
Organism-3： Rat
基因ID-3： 83825
SwissProt-3： O08875
背景： This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],
细胞定位： intracellular,integral component of plasma membrane,postsynaptic density,
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1138R
特异性： Endogenous
基因名称： DCLK1 DCAMKL1 DCDC3A KIAA0369
蛋白名称： DCLK1
Organism-1： Human
基因ID-1： 9201
SwissProt-1： O15075
Organism-2： Mouse
基因ID-2： 13175
SwissProt-2： Q9JLM8
Organism-3： Rat
基因ID-3： 83825
SwissProt-3： O08875
背景： This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],
细胞定位： intracellular,integral component of plasma membrane,postsynaptic density,
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