储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1044R
特异性： Endogenous
基因名称： DGCR8 C22orf12 DGCRK6 LP4941
蛋白名称： DGCR8
别名： Microprocessor complex subunit DGCR8;DiGeorge syndrome critical region 8;
Organism-1： Human
基因ID-1： 54487
SwissProt-1： Q8WYQ5
Organism-2： Mouse
基因ID-2： 94223
SwissProt-2： Q9EQM6
背景： This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
细胞定位： Nucleus . Nucleus, nucleolus . Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT1044R
特异性： Endogenous
基因名称： DGCR8 C22orf12 DGCRK6 LP4941
蛋白名称： DGCR8
别名： Microprocessor complex subunit DGCR8;DiGeorge syndrome critical region 8;
Organism-1： Human
基因ID-1： 54487
SwissProt-1： Q8WYQ5
Organism-2： Mouse
基因ID-2： 94223
SwissProt-2： Q9EQM6
背景： This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
细胞定位： Nucleus . Nucleus, nucleolus . Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
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