储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0883R
特异性： Endogenous
基因名称： SREBF1 BHLHD1 SREBP1
蛋白名称： SREBP-1
别名： Sterol regulatory element-binding protein 1;SREBP-1;Class D basic helix-loop-helix protein 1;bHLHd1;Sterol regulatory element-binding transcription factor 1;[Cleaved into: Processed sterol regulatory element-binding protein 1]
Organism-1： Human
基因ID-1： 6720
SwissProt-1： P36956
Organism-2： Mouse
基因ID-2： 20787
SwissProt-2： Q9WTN3
Organism-3： Rat
基因ID-3： 78968
SwissProt-3： P56720
背景： This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],
细胞定位： [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. .; [Processed sterol regulatory element-binding protein 1]: Nucleus .; [Isoform SREBP-1aDelta]: Nucleus .; [Isoform SREBP-1cDelta]: Nucleus .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0883R
特异性： Endogenous
基因名称： SREBF1 BHLHD1 SREBP1
蛋白名称： SREBP-1
别名： Sterol regulatory element-binding protein 1;SREBP-1;Class D basic helix-loop-helix protein 1;bHLHd1;Sterol regulatory element-binding transcription factor 1;[Cleaved into: Processed sterol regulatory element-binding protein 1]
Organism-1： Human
基因ID-1： 6720
SwissProt-1： P36956
Organism-2： Mouse
基因ID-2： 20787
SwissProt-2： Q9WTN3
Organism-3： Rat
基因ID-3： 78968
SwissProt-3： P56720
背景： This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],
细胞定位： [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. .; [Processed sterol regulatory element-binding protein 1]: Nucleus .; [Isoform SREBP-1aDelta]: Nucleus .; [Isoform SREBP-1cDelta]: Nucleus .
在线咨询
湘公网安备