储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT1131R
特异性： Endogenous
基因名称： AZU1
蛋白名称： Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP)
Organism-1： Human
基因ID-1： 566
SwissProt-1： P20160
背景： Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015],
细胞定位： Cytoplasmic granule membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT1131R
特异性： Endogenous
基因名称： AZU1
蛋白名称： Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP)
Organism-1： Human
基因ID-1： 566
SwissProt-1： P20160
背景： Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015],
细胞定位： Cytoplasmic granule membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. .
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