储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号: PT1082R
特异性: Endogenous
基因名称: RNF115,ZNF364
蛋白名称: E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
别名: ZNF364
Organism-1: Human
基因ID-1: 27246
SwissProt-1: Q9Y4L5
Organism-2: Mouse
基因ID-2: 67845
SwissProt-2: Q9D0C1
背景: Enables ubiquitin protein ligase activity. Involved in negative regulation of signal transduction; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
细胞定位: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20019814, ECO:0000269|PubMed:24852021}. Nucleus {ECO:0000269|PubMed:24852021}. Endoplasmic reticulum {ECO:0000269|PubMed:35343654}. Golgi apparatus {ECO:0000269|PubMed:35343654}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000269|PubMed:20019814, ECO:0000269|PubMed:24852021}.
储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号: PT1082R
特异性: Endogenous
基因名称: RNF115,ZNF364
蛋白名称: E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
别名: ZNF364
Organism-1: Human
基因ID-1: 27246
SwissProt-1: Q9Y4L5
Organism-2: Mouse
基因ID-2: 67845
SwissProt-2: Q9D0C1
背景: Enables ubiquitin protein ligase activity. Involved in negative regulation of signal transduction; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
细胞定位: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20019814, ECO:0000269|PubMed:24852021}. Nucleus {ECO:0000269|PubMed:24852021}. Endoplasmic reticulum {ECO:0000269|PubMed:35343654}. Golgi apparatus {ECO:0000269|PubMed:35343654}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000269|PubMed:20019814, ECO:0000269|PubMed:24852021}.