ErbB-3 (Phospho Tyr1289) Rabbit mAb

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商品货号： PRM8714

适应性： 人,小鼠,大鼠

￥7000元

规格：

500ul

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说明书

商品描述

发货日期：现货
靶点-Target： ErbB-3/her2
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 148kD
MW(Observed)： 185kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG, Kappa
偶联-Conjugate： Phospho
修饰-Modification： Tyr1289
推荐稀释比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0990R
特异性： Phospho-ErbB-3 (Y1289) Monoclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1289.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QGyEE
基因名称： ERBB3
蛋白名称： Receptor tyrosine-protein kinase erbB-3
别名： ERBB3;HER3;Receptor tyrosine-protein kinase erbB-3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
Organism-1： Human
基因ID-1： 2065
SwissProt-1： P21860
Organism-2： Mouse
基因ID-2： 13867
SwissProt-2： Q61526
Organism-3： Rat
基因ID-3： 29496
SwissProt-3： Q62799
背景： This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m
细胞定位： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

ErbB-3 (Phospho Tyr1289) Rabbit mAb

Catalog No PRM8714

Product information

发货日期：现货
靶点-Target： ErbB-3/her2
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 148kD
MW(Observed)： 185kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG, Kappa
偶联-Conjugate： Phospho
修饰-Modification： Tyr1289
推荐稀释比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0990R
特异性： Phospho-ErbB-3 (Y1289) Monoclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1289.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QGyEE
基因名称： ERBB3
蛋白名称： Receptor tyrosine-protein kinase erbB-3
别名： ERBB3;HER3;Receptor tyrosine-protein kinase erbB-3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
Organism-1： Human
基因ID-1： 2065
SwissProt-1： P21860
Organism-2： Mouse
基因ID-2： 13867
SwissProt-2： Q61526
Organism-3： Rat
基因ID-3： 29496
SwissProt-3： Q62799
背景： This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m
细胞定位： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

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