STAT6 (Phospho Tyr641) Rabbit mAb

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商品货号： PRM8678

适应性： 人,小鼠,大鼠

￥800元

规格：

50ul

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说明书

商品描述

发货日期：现货
靶点-Target： Stat6
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 94kD
MW(Observed)： 110kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Phospho
修饰-Modification： Tyr641
推荐稀释比： IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0917R
特异性： Phospho-Stat6 (Y641) Antibody detects endogenous levels of Stat6 protein only when phosphorylated at Y641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGyVP
基因名称： STAT6
蛋白名称： Signal transducer and activator of transcription 6
别名： STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
Organism-1： Human
基因ID-1： 6778
SwissProt-1： P42226
Organism-2： Mouse
基因ID-2： 20852
SwissProt-2： P52633
背景： The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
细胞定位： Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

STAT6 (Phospho Tyr641) Rabbit mAb

Catalog No PRM8678

Product information

发货日期：现货
靶点-Target： Stat6
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 94kD
MW(Observed)： 110kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Phospho
修饰-Modification： Tyr641
推荐稀释比： IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0917R
特异性： Phospho-Stat6 (Y641) Antibody detects endogenous levels of Stat6 protein only when phosphorylated at Y641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGyVP
基因名称： STAT6
蛋白名称： Signal transducer and activator of transcription 6
别名： STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
Organism-1： Human
基因ID-1： 6778
SwissProt-1： P42226
Organism-2： Mouse
基因ID-2： 20852
SwissProt-2： P52633
背景： The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
细胞定位： Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

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