储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0876R
特异性： Endogenous
基因名称： BRCA1
蛋白名称： Breast cancer type 1 susceptibility protein
别名： BRCA1;RNF53;Breast cancer type 1 susceptibility protein;RING finger protein 53
Organism-1： Human
基因ID-1： 672
SwissProt-1： P38398
Organism-2： Mouse
SwissProt-2： P48754
Organism-3： Rat
基因ID-3： 497672
SwissProt-3： O54952
背景： This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
细胞定位： Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0876R
特异性： Endogenous
基因名称： BRCA1
蛋白名称： Breast cancer type 1 susceptibility protein
别名： BRCA1;RNF53;Breast cancer type 1 susceptibility protein;RING finger protein 53
Organism-1： Human
基因ID-1： 672
SwissProt-1： P38398
Organism-2： Mouse
SwissProt-2： P48754
Organism-3： Rat
基因ID-3： 497672
SwissProt-3： O54952
背景： This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
细胞定位： Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm .
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