储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0970R
特异性： Endogenous
基因名称： FBXO32
蛋白名称： FBX32
别名： F-box only protein 32;Atrogin-1;Muscle atrophy F-box protein;MAFbx;
Organism-1： Human
基因ID-1： 114907
SwissProt-1： Q969P5
Organism-2： Mouse
基因ID-2： 67731
SwissProt-2： Q9CPU7
Organism-3： Rat
基因ID-3： 171043
SwissProt-3： Q91Z62
背景： This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
细胞定位： Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆号： PT0970R
特异性： Endogenous
基因名称： FBXO32
蛋白名称： FBX32
别名： F-box only protein 32;Atrogin-1;Muscle atrophy F-box protein;MAFbx;
Organism-1： Human
基因ID-1： 114907
SwissProt-1： Q969P5
Organism-2： Mouse
基因ID-2： 67731
SwissProt-2： Q9CPU7
Organism-3： Rat
基因ID-3： 171043
SwissProt-3： Q91Z62
背景： This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
细胞定位： Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
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