储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0088R
特异性： Endogenous
基因名称： RHOA ARH12 ARHA RHO12
蛋白名称： Rho A
别名： Transforming protein RhoA;Rho cDNA clone 12;h12;
Organism-1： Human
基因ID-1： 387
SwissProt-1： P61586
Organism-2： Mouse
基因ID-2： 11848
SwissProt-2： Q9QUI0
Organism-3： Rat
基因ID-3： 117273
SwissProt-3： P61589
背景： This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
细胞定位： Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex . Midbody. Cell projection, lamellipodium . Cell projection, dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0088R
特异性： Endogenous
基因名称： RHOA ARH12 ARHA RHO12
蛋白名称： Rho A
别名： Transforming protein RhoA;Rho cDNA clone 12;h12;
Organism-1： Human
基因ID-1： 387
SwissProt-1： P61586
Organism-2： Mouse
基因ID-2： 11848
SwissProt-2： Q9QUI0
Organism-3： Rat
基因ID-3： 117273
SwissProt-3： P61589
背景： This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
细胞定位： Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex . Midbody. Cell projection, lamellipodium . Cell projection, dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .
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