储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0301R
特异性： Endogenous
基因名称： BAX
蛋白名称： Apoptosis regulator BAX
别名： BAX;BCL2L4;Apoptosis regulator BAX;Bcl-2-like protein 4;Bcl2-L-4
Organism-1： Human
基因ID-1： 581
SwissProt-1： Q07812
Organism-2： Mouse
基因ID-2： 12028
SwissProt-2： Q07813
Organism-3： Rat
SwissProt-3： Q63690
背景： The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0301R
特异性： Endogenous
基因名称： BAX
蛋白名称： Apoptosis regulator BAX
别名： BAX;BCL2L4;Apoptosis regulator BAX;Bcl-2-like protein 4;Bcl2-L-4
Organism-1： Human
基因ID-1： 581
SwissProt-1： Q07812
Organism-2： Mouse
基因ID-2： 12028
SwissProt-2： Q07813
Organism-3： Rat
SwissProt-3： Q63690
背景： The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
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