储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆号: PT0368R
特异性: Endogenous
基因名称: TGFBR2
蛋白名称: TGF-beta receptor type-2
别名: TGFBR2;TGF-beta receptor type-2;TGFR-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II
Organism-1: Human
基因ID-1: 7048
SwissProt-1: P37173
Organism-2: Mouse
基因ID-2: 21813
SwissProt-2: Q62312
Organism-3: Rat
基因ID-3: 81810
SwissProt-3: P38438
背景: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],
储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆号: PT0368R
特异性: Endogenous
基因名称: TGFBR2
蛋白名称: TGF-beta receptor type-2
别名: TGFBR2;TGF-beta receptor type-2;TGFR-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II
Organism-1: Human
基因ID-1: 7048
SwissProt-1: P37173
Organism-2: Mouse
基因ID-2: 21813
SwissProt-2: Q62312
Organism-3: Rat
基因ID-3: 81810
SwissProt-3: P38438
背景: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],