储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0804R
特异性： Endogenous
基因名称： FAM111A;KIAA1895
蛋白名称： Serine protease FAM111A
别名： FAM111A;KIAA1895;Serine protease FAM111A;
Organism-1： Human
基因ID-1： 63901
SwissProt-1： Q96PZ2
Organism-2： Mouse
基因ID-2： 107373
SwissProt-2： Q9D2L9
背景： The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
细胞定位： Nucleus. Chromosome. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites..
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0804R
特异性： Endogenous
基因名称： FAM111A;KIAA1895
蛋白名称： Serine protease FAM111A
别名： FAM111A;KIAA1895;Serine protease FAM111A;
Organism-1： Human
基因ID-1： 63901
SwissProt-1： Q96PZ2
Organism-2： Mouse
基因ID-2： 107373
SwissProt-2： Q9D2L9
背景： The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
细胞定位： Nucleus. Chromosome. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites..
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