储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0652R
特异性： Endogenous
基因名称： TBC1D4
蛋白名称： TBC1 domain family member 4
别名： TBC1D4;AS160;KIAA0603;TBC1 domain family member 4;Akt substrate of 160 kDa;AS160
Organism-1： Human
基因ID-1： 9882
SwissProt-1： O60343
Organism-2： Mouse
基因ID-2： 210789
SwissProt-2： Q8BYJ6
背景： This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0652R
特异性： Endogenous
基因名称： TBC1D4
蛋白名称： TBC1 domain family member 4
别名： TBC1D4;AS160;KIAA0603;TBC1 domain family member 4;Akt substrate of 160 kDa;AS160
Organism-1： Human
基因ID-1： 9882
SwissProt-1： O60343
Organism-2： Mouse
基因ID-2： 210789
SwissProt-2： Q8BYJ6
背景： This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph
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