储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0650R
特异性： Endogenous
基因名称： AIFM1 ALF PDCD8
蛋白名称： Apoptosis-inducing factor 1 mitochondrial
别名： AIFM1;AIF;PDCD8;Apoptosis-inducing factor 1;mitochondrial;Programmed cell death protein 8
Organism-1： Human
基因ID-1： 9131
SwissProt-1： O95831
Organism-2： Mouse
基因ID-2： 26926
SwissProt-2： Q9Z0X1
Organism-3： Rat
基因ID-3： 83533
SwissProt-3： Q9JM53
背景： This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
细胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0650R
特异性： Endogenous
基因名称： AIFM1 ALF PDCD8
蛋白名称： Apoptosis-inducing factor 1 mitochondrial
别名： AIFM1;AIF;PDCD8;Apoptosis-inducing factor 1;mitochondrial;Programmed cell death protein 8
Organism-1： Human
基因ID-1： 9131
SwissProt-1： O95831
Organism-2： Mouse
基因ID-2： 26926
SwissProt-2： Q9Z0X1
Organism-3： Rat
基因ID-3： 83533
SwissProt-3： Q9JM53
背景： This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
细胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
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