储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0646R
特异性： Endogenous
基因名称： MLKL
蛋白名称： Mixed lineage kinase domain-like protein
别名： MLKL;Mixed lineage kinase domain-like protein
Organism-1： Human
基因ID-1： 197259
SwissProt-1： Q8NB16
Organism-2： Mouse
SwissProt-2： Q9D2Y4
背景： This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0646R
特异性： Endogenous
基因名称： MLKL
蛋白名称： Mixed lineage kinase domain-like protein
别名： MLKL;Mixed lineage kinase domain-like protein
Organism-1： Human
基因ID-1： 197259
SwissProt-1： Q8NB16
Organism-2： Mouse
SwissProt-2： Q9D2Y4
背景： This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
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