储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0647R
特异性： Endogenous
基因名称： PDPK1
蛋白名称： 3-phosphoinositide-dependent protein kinase 1
别名： PDPK1;PDK1;3-phosphoinositide-dependent protein kinase 1;hPDK1
Organism-1： Human
基因ID-1： 5170
SwissProt-1： O15530
Organism-2： Mouse
基因ID-2： 18607
SwissProt-2： Q9Z2A0
Organism-3： Rat
基因ID-3： 81745
SwissProt-3： O55173
背景： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0647R
特异性： Endogenous
基因名称： PDPK1
蛋白名称： 3-phosphoinositide-dependent protein kinase 1
别名： PDPK1;PDK1;3-phosphoinositide-dependent protein kinase 1;hPDK1
Organism-1： Human
基因ID-1： 5170
SwissProt-1： O15530
Organism-2： Mouse
基因ID-2： 18607
SwissProt-2： Q9Z2A0
Organism-3： Rat
基因ID-3： 81745
SwissProt-3： O55173
背景： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,
在线咨询
湘公网安备