储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆号: PT0683R
特异性: Endogenous
基因名称: PIK3C3 VPS34
蛋白名称: PI 3 Kinase Class 3
别名: phosphoinositide-3-kinase, class 3
Organism-1: Human
基因ID-1: 5289
SwissProt-1: Q8NEB9
Organism-2: Mouse
基因ID-2: 225326
SwissProt-2: Q6PF93
Organism-3: Rat
SwissProt-3: O88763
背景: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,
细胞定位: Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .
储存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性: Monoclonal
克隆号: PT0683R
特异性: Endogenous
基因名称: PIK3C3 VPS34
蛋白名称: PI 3 Kinase Class 3
别名: phosphoinositide-3-kinase, class 3
Organism-1: Human
基因ID-1: 5289
SwissProt-1: Q8NEB9
Organism-2: Mouse
基因ID-2: 225326
SwissProt-2: Q6PF93
Organism-3: Rat
SwissProt-3: O88763
背景: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,
细胞定位: Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .