4E-BP1 (Phospho 4E-BP1 (Phospho Thr37/46)) Rabbit mAb

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商品货号： PRM8021

适应性： 人,小鼠,大鼠

￥7000元

规格：

500ul

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说明书

商品描述

发货日期：现货
靶点-Target： 4E BP1
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 13kD
MW(Observed)： 15-20kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Phospho
修饰-Modification： Thr37/46
推荐稀释比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0862R
特异性： 4E-BP1 (Phospho Thr37/46) Antibody detects endogenous levels of 4E-BP1 protein only when phosphorylated at 4E-BP1 (Phospho T37/46).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TTpGG
基因名称： EIF4EBP1
蛋白名称： Eukaryotic translation initiation factor 4E-binding protein 1
别名： EIF4EBP1;Eukaryotic translation initiation factor 4E-binding protein 1;4E-BP1;eIF4E-binding protein 1;Phosphorylated heat- and acid-stable protein regulated by insulin 1;PHAS-I
Organism-1： Human
基因ID-1： 1978
SwissProt-1： Q13541
Organism-2： Mouse
基因ID-2： 13685
SwissProt-2： Q60876
Organism-3： Rat
基因ID-3： 116636
SwissProt-3： Q62622
背景： This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
细胞定位： Nucleus

4E-BP1 (Phospho 4E-BP1 (Phospho Thr37/46)) Rabbit mAb

Catalog No PRM8021

Product information

发货日期：现货
靶点-Target： 4E BP1
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 13kD
MW(Observed)： 15-20kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Phospho
修饰-Modification： Thr37/46
推荐稀释比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0862R
特异性： 4E-BP1 (Phospho Thr37/46) Antibody detects endogenous levels of 4E-BP1 protein only when phosphorylated at 4E-BP1 (Phospho T37/46).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TTpGG
基因名称： EIF4EBP1
蛋白名称： Eukaryotic translation initiation factor 4E-binding protein 1
别名： EIF4EBP1;Eukaryotic translation initiation factor 4E-binding protein 1;4E-BP1;eIF4E-binding protein 1;Phosphorylated heat- and acid-stable protein regulated by insulin 1;PHAS-I
Organism-1： Human
基因ID-1： 1978
SwissProt-1： Q13541
Organism-2： Mouse
基因ID-2： 13685
SwissProt-2： Q60876
Organism-3： Rat
基因ID-3： 116636
SwissProt-3： Q62622
背景： This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
细胞定位： Nucleus

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