Doublecortin Rabbit mAb

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商品货号： PRM8008

适应性： 人,小鼠,大鼠

￥7000元

规格：

500ul

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说明书

商品描述

发货日期：现货
靶点-Target： Doublecortin
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 41kD
MW(Observed)： 41kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Unmodified
推荐稀释比： IHC 1:50-1:200;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0871R
特异性： Endogenous
基因名称： DCX
蛋白名称： Neuronal migration protein doublecortin
别名： DCX;DBCN;LISX;Neuronal migration protein doublecortin;Doublin;Lissencephalin-X;Lis-X
Organism-1： Human
基因ID-1： 1641
SwissProt-1： O43602
Organism-2： Mouse
基因ID-2： 13193
SwissProt-2： O88809
Organism-3： Rat
SwissProt-3： Q9ESI7
背景： This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo
细胞定位： Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. .

Doublecortin Rabbit mAb

Catalog No PRM8008

Product information

发货日期：现货
靶点-Target： Doublecortin
反应性-Reactivity：人,小鼠,大鼠
应用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 41kD
MW(Observed)： 41kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
偶联-Conjugate： Unmodified
推荐稀释比： IHC 1:50-1:200;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0871R
特异性： Endogenous
基因名称： DCX
蛋白名称： Neuronal migration protein doublecortin
别名： DCX;DBCN;LISX;Neuronal migration protein doublecortin;Doublin;Lissencephalin-X;Lis-X
Organism-1： Human
基因ID-1： 1641
SwissProt-1： O43602
Organism-2： Mouse
基因ID-2： 13193
SwissProt-2： O88809
Organism-3： Rat
SwissProt-3： Q9ESI7
背景： This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo
细胞定位： Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. .

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