Akt (pan) (Phospho Ser473) (PT0470R) PT® Rabbit mAb

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商品货号： PLR10305

适应性： 人,小鼠,大鼠,

￥1200元

规格：

100μL

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说明书

商品描述

靶点-Target： Akt1/2/3
MW(Calculated)： 55kD
MW(Observed)： 60kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Phospho
修饰位点： Ser473
推荐稀释比： IHC 1:200-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0470R
特异性： This antibody detects endogenous levels of Phospho Akt1 only when phosphorylated at Ser473. This antibody also recognizes Akt2 and Akt3 when phosphorylated at the corresponding sites.
基因名称： AKT1/AKT2/AKT3
蛋白名称： RAC-alpha serine/threonine-protein kinase;RAC-beta serine/threonine-protein kinase;RAC-gamma serine/threonine-protein kinase
Organism-1：人
基因ID-1： 207;208;10000
SwissProt-1： P31749;P31751;Q9Y243
Organism-2： Mouse
基因ID-2： 11651;11652;23797
SwissProt-2： P31750
Organism-3： Rat
基因ID-3： 24185;25233;29414
SwissProt-3： P47196;P47197;Q63484
细胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
组织表达： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all 人 cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.

Akt (pan) (Phospho Ser473) (PT0470R) PT® Rabbit mAb

Catalog No PLR10305

Product information

靶点-Target： Akt1/2/3
MW(Calculated)： 55kD
MW(Observed)： 60kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Phospho
修饰位点： Ser473
推荐稀释比： IHC 1:200-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0470R
特异性： This antibody detects endogenous levels of Phospho Akt1 only when phosphorylated at Ser473. This antibody also recognizes Akt2 and Akt3 when phosphorylated at the corresponding sites.
基因名称： AKT1/AKT2/AKT3
蛋白名称： RAC-alpha serine/threonine-protein kinase;RAC-beta serine/threonine-protein kinase;RAC-gamma serine/threonine-protein kinase
Organism-1：人
基因ID-1： 207;208;10000
SwissProt-1： P31749;P31751;Q9Y243
Organism-2： Mouse
基因ID-2： 11651;11652;23797
SwissProt-2： P31750
Organism-3： Rat
基因ID-3： 24185;25233;29414
SwissProt-3： P47196;P47197;Q63484
细胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
组织表达： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all 人 cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.

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