AIFM1 (PT0650R) PT® Rabbit mAb

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商品货号： PLR10096

适应性： 人,小鼠,大鼠,

￥1200元

规格：

100μL

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商品描述

靶点-Target： AIFM1
MW(Calculated)： 67kD
MW(Observed)： 67kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Unmodified
推荐稀释比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0650R
特异性： Endogenous
基因名称： AIFM1 ALF PDCD8
蛋白名称： Apoptosis-inducing factor 1 mitochondrial
别名： AIFM1;AIF;PDCD8;Apoptosis-inducing factor 1;mitochondrial;Programmed cell death protein 8
Organism-1：人
基因ID-1： 9131
SwissProt-1： O95831
Organism-2： Mouse
基因ID-2： 26926
SwissProt-2： Q9Z0X1
Organism-3： Rat
基因ID-3： 83533
SwissProt-3： Q9JM53
细胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
组织表达： Expressed in all tested tissues (PubMed:16644725). Detected in muscle and skin fibroblasts (at protein level) (PubMed:23217327). Expressed in osteoblasts (at protein level) (PubMed:28842795). ; [Isoform 3]: Brain specific. ; [Isoform 4]: Expressed in all tested tissues except brain. ; [Isoform 5]: Isoform 5 is frequently down-regulated in 人 cancers.

AIFM1 (PT0650R) PT® Rabbit mAb

Catalog No PLR10096

Product information

靶点-Target： AIFM1
MW(Calculated)： 67kD
MW(Observed)： 67kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Unmodified
推荐稀释比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0650R
特异性： Endogenous
基因名称： AIFM1 ALF PDCD8
蛋白名称： Apoptosis-inducing factor 1 mitochondrial
别名： AIFM1;AIF;PDCD8;Apoptosis-inducing factor 1;mitochondrial;Programmed cell death protein 8
Organism-1：人
基因ID-1： 9131
SwissProt-1： O95831
Organism-2： Mouse
基因ID-2： 26926
SwissProt-2： Q9Z0X1
Organism-3： Rat
基因ID-3： 83533
SwissProt-3： Q9JM53
细胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
组织表达： Expressed in all tested tissues (PubMed:16644725). Detected in muscle and skin fibroblasts (at protein level) (PubMed:23217327). Expressed in osteoblasts (at protein level) (PubMed:28842795). ; [Isoform 3]: Brain specific. ; [Isoform 4]: Expressed in all tested tissues except brain. ; [Isoform 5]: Isoform 5 is frequently down-regulated in 人 cancers.

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