Smad2/3 (Phospho Thr8) (PT0741R) PT® Rabbit mAb

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商品货号： PLR10011

适应性： 人,小鼠,大鼠

￥1200元

规格：

100μL

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说明书

商品描述

靶点-Target： Smad2/3
MW(Calculated)： 48kD
MW(Observed)： 62kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Phospho
修饰位点： Thr8
推荐稀释比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0741R
特异性： Phospho-Smad2/3 (T8) Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in 人 samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PFtPP
基因名称： SMAD2/SMAD3
蛋白名称： Mothers against decapentaplegic homolog 2/3
别名： SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;SMAD3;MADH3;Mothers against decapentaplegic
Organism-1：人
基因ID-1： 4087;4088
SwissProt-1： Q15796;P84022
Organism-2： Mouse
基因ID-2： 17126;17127
Organism-3： Rat
基因ID-3： 29357;25631
SwissProt-3： O70436;P84025
细胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
组织表达： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Smad2/3 (Phospho Thr8) (PT0741R) PT® Rabbit mAb

Catalog No PLR10011

Product information

靶点-Target： Smad2/3
MW(Calculated)： 48kD
MW(Observed)： 62kD
宿主物种-Host Species： Rabbit
同种型-Isotype： IgG,Kappa
修饰-Modification： Phospho
修饰位点： Thr8
推荐稀释比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺： Protein A
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆号： PT0741R
特异性： Phospho-Smad2/3 (T8) Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in 人 samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PFtPP
基因名称： SMAD2/SMAD3
蛋白名称： Mothers against decapentaplegic homolog 2/3
别名： SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;SMAD3;MADH3;Mothers against decapentaplegic
Organism-1：人
基因ID-1： 4087;4088
SwissProt-1： Q15796;P84022
Organism-2： Mouse
基因ID-2： 17126;17127
Organism-3： Rat
基因ID-3： 29357;25631
SwissProt-3： O70436;P84025
细胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
组织表达： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

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