其他名称: Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
实测条带: 21kD
功能: function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm . Nucleus .
组织表达: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
科研货号: PLP001783
p21Cip1 (Phospho Thr57) Rabbit pAb
Catalog NoPLP001783
Product information
基因名称: CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
蛋白名称: Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
其他名称: Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
实测条带: 21kD
功能: function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm . Nucleus .
组织表达: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.