其他名称： Polymerase I and transcript release factor (Cavin-1)
实测条带： 55kD
功能： function:Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.,PTM:Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.,PTM:Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity.,similarity:Belongs to the PTRF/SDPR family.,subcellular location:Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with RNA polymerase I and TTF1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm.,
细胞定位： Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity). .
其他名称： Polymerase I and transcript release factor (Cavin-1)
实测条带： 55kD
功能： function:Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.,PTM:Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.,PTM:Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity.,similarity:Belongs to the PTRF/SDPR family.,subcellular location:Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with RNA polymerase I and TTF1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm.,
细胞定位： Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity). .
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