TIF1β (Phospho Ser824) rabbit pAb

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商品货号： PLP001488

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： TRIM28 KAP1 RNF96 TIF1B
蛋白名称： TIF1β (Ser824)
Human_gene_id： 10155
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10155
Human_swiss_prot_no： Q13263
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q13263/entry
Mouse_gene_id： 21849
Mouse_gene_link： https://www.uniprot.org/uniprot/21849
Mouse_swiss_prot_no： Q62318
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q62318
Rat_gene_id： 116698
Rat_gene_link： https://www.uniprot.org/uniprot/116698
Rat_swiss_prot_no： O08629
Rat_swiss_link： https://www.uniprot.org/uniprotkb/O08629
特异性： This antibody detects endogenous levels of Human TIF1β (phospho-Ser824)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28)
实测条带： 110kD
功能： domain:Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.,domain:The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity.,function:Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subcellular location:Associated with centromeric heterochromatin during cell differentiation through CBX1.,subunit:Associated with HP1 alpha (CBX5), beta (CBX1) and gamma (CBX3) in interphase nuclei (By similarity). Interacts with ZNF382; enhances ZNF382 transcriptional repressor activity (By similarity). Interacts with CEBPB and NR3C1 (By similarity). Interacts with NCOR1 and CHD3. Interacts with SETDB1, ZFP53 and ZFP68. Interacts directly with CBX5 via the PxVxL motif.,
相关产品： YM1235,YM1107,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Associated with centromeric heterochromatin during cell differentiation through CBX1. .
组织表达： Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
科研货号： PLP001488

TIF1β (Phospho Ser824) rabbit pAb

Catalog No PLP001488

Product information

基因名称： TRIM28 KAP1 RNF96 TIF1B
蛋白名称： TIF1β (Ser824)
Human_gene_id： 10155
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10155
Human_swiss_prot_no： Q13263
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q13263/entry
Mouse_gene_id： 21849
Mouse_gene_link： https://www.uniprot.org/uniprot/21849
Mouse_swiss_prot_no： Q62318
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q62318
Rat_gene_id： 116698
Rat_gene_link： https://www.uniprot.org/uniprot/116698
Rat_swiss_prot_no： O08629
Rat_swiss_link： https://www.uniprot.org/uniprotkb/O08629
特异性： This antibody detects endogenous levels of Human TIF1β (phospho-Ser824)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28)
实测条带： 110kD
功能： domain:Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.,domain:The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity.,function:Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subcellular location:Associated with centromeric heterochromatin during cell differentiation through CBX1.,subunit:Associated with HP1 alpha (CBX5), beta (CBX1) and gamma (CBX3) in interphase nuclei (By similarity). Interacts with ZNF382; enhances ZNF382 transcriptional repressor activity (By similarity). Interacts with CEBPB and NR3C1 (By similarity). Interacts with NCOR1 and CHD3. Interacts with SETDB1, ZFP53 and ZFP68. Interacts directly with CBX5 via the PxVxL motif.,
相关产品： YM1235,YM1107,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Associated with centromeric heterochromatin during cell differentiation through CBX1. .
组织表达： Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
科研货号： PLP001488

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