其他名称： Signal transducer and activator of transcription 5B
实测条带： 90kD
信号通路： ErbB_HER;Chemokine;Jak_STAT;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
功能： disease:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.,function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,online information:STAT5B mutation db,PTM:Tyrosine phosphorylated.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.,
相关产品： YM3465,YM0599,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .
其他名称： Signal transducer and activator of transcription 5B
实测条带： 90kD
信号通路： ErbB_HER;Chemokine;Jak_STAT;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
功能： disease:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.,function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,online information:STAT5B mutation db,PTM:Tyrosine phosphorylated.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.,
相关产品： YM3465,YM0599,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .
在线咨询
湘公网安备