PRK1 (Phospho Thr774)/PRK2 (Phospho Thr816) rabbit pAb

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商品货号： PLP001417

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

蛋白名称： PRK1 (Thr774)/PRK2 (Thr816)
Human_gene_id： 5585
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5585
Human_swiss_prot_no： Q16512
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q16512/entry
Mouse_gene_id： 320795
Mouse_gene_link： https://www.uniprot.org/uniprot/320795
Mouse_swiss_prot_no： P70268
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P70268
Rat_gene_id： 29355
Rat_gene_link： https://www.uniprot.org/uniprot/29355
Rat_swiss_prot_no： Q63433
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q63433
特异性： This antibody detects endogenous levels of Human Mouse Rat PRK1 (phospho-Thr774) or PRK2 (phospho-Thr816)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
实测条带： 103kD
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.,function:Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling.,PTM:Activated by limited proteolysis with trypsin.,PTM:Autophosphorylated; preferably on serine.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,subunit:Interacts with ZA20D3 (By similarity). Interacts with RhoA and Rac1.,tissue specificity:Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.,
相关产品： YT3778,YN0043,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Endosome . Cell membrane ; Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. .
组织表达： Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
科研货号： PLP001417

PRK1 (Phospho Thr774)/PRK2 (Phospho Thr816) rabbit pAb

Catalog No PLP001417

Product information

蛋白名称： PRK1 (Thr774)/PRK2 (Thr816)
Human_gene_id： 5585
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5585
Human_swiss_prot_no： Q16512
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q16512/entry
Mouse_gene_id： 320795
Mouse_gene_link： https://www.uniprot.org/uniprot/320795
Mouse_swiss_prot_no： P70268
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P70268
Rat_gene_id： 29355
Rat_gene_link： https://www.uniprot.org/uniprot/29355
Rat_swiss_prot_no： Q63433
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q63433
特异性： This antibody detects endogenous levels of Human Mouse Rat PRK1 (phospho-Thr774) or PRK2 (phospho-Thr816)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
实测条带： 103kD
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.,function:Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling.,PTM:Activated by limited proteolysis with trypsin.,PTM:Autophosphorylated; preferably on serine.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,subunit:Interacts with ZA20D3 (By similarity). Interacts with RhoA and Rac1.,tissue specificity:Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.,
相关产品： YT3778,YN0043,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Endosome . Cell membrane ; Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. .
组织表达： Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
科研货号： PLP001417

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