PKM2 (Phospho Tyr105) rabbit pAb

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商品货号： PLP001410

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PKM OIP3 PK2 PK3 PKM2
蛋白名称： PKM2 (Tyr105)
Human_gene_id： 5315
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5315
Human_swiss_prot_no： P14618
Human_swiss_link： https://www.uniprot.org/uniprotkb/P14618/entry
Mouse_gene_id： 18746
Mouse_gene_link： https://www.uniprot.org/uniprot/18746
Mouse_swiss_prot_no： P52480
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P52480
Rat_gene_id： 25630
Rat_gene_link： https://www.uniprot.org/uniprot/25630
Rat_swiss_prot_no： P11980
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P11980
特异性： This antibody detects endogenous levels of Human Mouse Rat PKM2 (phospho-Tyr105)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58)
实测条带： 58kD
信号通路： Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus;
功能： catalytic activity:ATP + pyruvate = ADP + phosphoenolpyruvate.,cofactor:Divalent metal cations.,cofactor:Magnesium.,cofactor:Potassium.,enzyme regulation:Isoform M2 is allosterically activated by D-fructose 1,6-biphosphate (FBP). Inhibited by oxalate and 3,3',5-triiodo-L-thyronine (T3).,function:Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.,miscellaneous:There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.,online information:Pyruvate kinase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the pyruvate kinase family.,subunit:Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. Interacts with HERC1.,
相关产品： YT3777,YM1323,YM1322,RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform M2]: Cytoplasm . Nucleus . Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). .; [Isoform M1]: Cytoplasm .
组织表达： [Isoform M2]: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. ; [Isoform M1]: Expressed in adult tissues (PubMed:18337823). Not expressed in tumor cells (PubMed:18337823).
科研货号： PLP001410

PKM2 (Phospho Tyr105) rabbit pAb

Catalog No PLP001410

Product information

基因名称： PKM OIP3 PK2 PK3 PKM2
蛋白名称： PKM2 (Tyr105)
Human_gene_id： 5315
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5315
Human_swiss_prot_no： P14618
Human_swiss_link： https://www.uniprot.org/uniprotkb/P14618/entry
Mouse_gene_id： 18746
Mouse_gene_link： https://www.uniprot.org/uniprot/18746
Mouse_swiss_prot_no： P52480
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P52480
Rat_gene_id： 25630
Rat_gene_link： https://www.uniprot.org/uniprot/25630
Rat_swiss_prot_no： P11980
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P11980
特异性： This antibody detects endogenous levels of Human Mouse Rat PKM2 (phospho-Tyr105)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58)
实测条带： 58kD
信号通路： Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus;
功能： catalytic activity:ATP + pyruvate = ADP + phosphoenolpyruvate.,cofactor:Divalent metal cations.,cofactor:Magnesium.,cofactor:Potassium.,enzyme regulation:Isoform M2 is allosterically activated by D-fructose 1,6-biphosphate (FBP). Inhibited by oxalate and 3,3',5-triiodo-L-thyronine (T3).,function:Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.,miscellaneous:There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.,online information:Pyruvate kinase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the pyruvate kinase family.,subunit:Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. Interacts with HERC1.,
相关产品： YT3777,YM1323,YM1322,RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform M2]: Cytoplasm . Nucleus . Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). .; [Isoform M1]: Cytoplasm .
组织表达： [Isoform M2]: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. ; [Isoform M1]: Expressed in adult tissues (PubMed:18337823). Not expressed in tumor cells (PubMed:18337823).
科研货号： PLP001410

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