Mcl-1 (Phospho Thr163) rabbit pAb

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商品货号： PLP001374

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MCL1 BCL2L3
蛋白名称： Mcl-1 (Thr163)
Human_gene_id： 4170
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4170
Human_swiss_prot_no： Q07820
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q07820/entry
Mouse_gene_id： 17210
Mouse_gene_link： https://www.uniprot.org/uniprot/17210
Mouse_swiss_prot_no： P97287
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P97287
Rat_gene_id： 60430
Rat_gene_link： https://www.uniprot.org/uniprot/60430
Rat_swiss_prot_no： Q9Z1P3
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9Z1P3
特异性： This antibody detects endogenous levels of Human Mcl-1 (phospho-Thr163)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
实测条带： About 40kd in human,39kd in mouse and rat
功能： function:Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.,induction:Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during retinoic acid-induced differentiation.,PTM:Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.,PTM:Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.,PTM:Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.,similarity:Belongs to the Bcl-2 family.,subcellular location:Cytoplasmic, associated with mitochondria.,subunit:Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptototic BCL2-related proteins.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass membrane protein . Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.
组织表达： Ewing sarcoma,Mammary gland,Myeloid leukemia cell,Neuroblastoma,Placenta,Th
科研货号： PLP001374

Mcl-1 (Phospho Thr163) rabbit pAb

Catalog No PLP001374

Product information

基因名称： MCL1 BCL2L3
蛋白名称： Mcl-1 (Thr163)
Human_gene_id： 4170
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4170
Human_swiss_prot_no： Q07820
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q07820/entry
Mouse_gene_id： 17210
Mouse_gene_link： https://www.uniprot.org/uniprot/17210
Mouse_swiss_prot_no： P97287
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P97287
Rat_gene_id： 60430
Rat_gene_link： https://www.uniprot.org/uniprot/60430
Rat_swiss_prot_no： Q9Z1P3
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9Z1P3
特异性： This antibody detects endogenous levels of Human Mcl-1 (phospho-Thr163)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
实测条带： About 40kd in human,39kd in mouse and rat
功能： function:Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.,induction:Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during retinoic acid-induced differentiation.,PTM:Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.,PTM:Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.,PTM:Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.,similarity:Belongs to the Bcl-2 family.,subcellular location:Cytoplasmic, associated with mitochondria.,subunit:Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptototic BCL2-related proteins.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass membrane protein . Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.
组织表达： Ewing sarcoma,Mammary gland,Myeloid leukemia cell,Neuroblastoma,Placenta,Th
科研货号： PLP001374

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