其他名称： Low-density lipoprotein receptor-related protein 6 (LRP-6)
实测条带： 177kD
信号通路： WNT;WNT-T CELL
功能： disease:Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947].,domain:The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1.,function:Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.,similarity:Belongs to the LDLR family.,similarity:Contains 20 LDL-receptor class B repeats.,similarity:Contains 3 LDL-receptor class A domains.,similarity:Contains 4 EGF-like domains.,subunit:Interacts with RSPO1 and RSPO3 (By similarity). Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.,tissue specificity:Widely co-expressed with LRP5 during embryogenesis and in adult tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). .
组织表达： Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
其他名称： Low-density lipoprotein receptor-related protein 6 (LRP-6)
实测条带： 177kD
信号通路： WNT;WNT-T CELL
功能： disease:Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947].,domain:The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1.,function:Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.,similarity:Belongs to the LDLR family.,similarity:Contains 20 LDL-receptor class B repeats.,similarity:Contains 3 LDL-receptor class A domains.,similarity:Contains 4 EGF-like domains.,subunit:Interacts with RSPO1 and RSPO3 (By similarity). Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.,tissue specificity:Widely co-expressed with LRP5 during embryogenesis and in adult tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). .
组织表达： Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
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