IRF-7 (Phospho Ser471/472) rabbit pAb

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商品货号： PLP001346

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： IRF7
蛋白名称： IRF-7 (Ser471/472)
Human_gene_id： 3665
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3665
Human_swiss_prot_no： Q92985
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92985/entry
Mouse_gene_id： 54123
Mouse_gene_link： https://www.uniprot.org/uniprot/54123
Mouse_swiss_prot_no： P70434
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P70434
特异性： This antibody detects endogenous levels of Human IRF-7 (phospho-Ser471 or 472) Mouse IRF-7 (phospho-Ser425 or 426), Rat IRF-7 (phospho-Ser423 or 424)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Interferon regulatory factor 7 (IRF-7)
实测条带： 55kD
信号通路： Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
功能： function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.,induction:By type I interferons.,PTM:In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subcellular location:The phosphorylated and active form accumulates selectively in the nucleus.,subunit:Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2.,tissue specificity:Expressed predominantly in spleen, thymus and peripheral blood leukocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
组织表达： Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
科研货号： PLP001346

IRF-7 (Phospho Ser471/472) rabbit pAb

Catalog No PLP001346

Product information

基因名称： IRF7
蛋白名称： IRF-7 (Ser471/472)
Human_gene_id： 3665
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3665
Human_swiss_prot_no： Q92985
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92985/entry
Mouse_gene_id： 54123
Mouse_gene_link： https://www.uniprot.org/uniprot/54123
Mouse_swiss_prot_no： P70434
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P70434
特异性： This antibody detects endogenous levels of Human IRF-7 (phospho-Ser471 or 472) Mouse IRF-7 (phospho-Ser425 or 426), Rat IRF-7 (phospho-Ser423 or 424)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Interferon regulatory factor 7 (IRF-7)
实测条带： 55kD
信号通路： Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
功能： function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.,induction:By type I interferons.,PTM:In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subcellular location:The phosphorylated and active form accumulates selectively in the nucleus.,subunit:Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2.,tissue specificity:Expressed predominantly in spleen, thymus and peripheral blood leukocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
组织表达： Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
科研货号： PLP001346

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