MYLK (phospho Tyr464) Polyclonal Antibody

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商品货号： PLP001111

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MYLK
蛋白名称： Myosin light chain kinase smooth muscle
Human_gene_id： 4638
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4638
Human_swiss_prot_no： Q15746
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15746/entry
Mouse_swiss_prot_no： Q6PDN3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6PDN3
特异性： Phospho-MYLK (Y464) Polyclonal Antibody detects endogenous levels of MYLK protein only when phosphorylated at Y464.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MYLK; MLCK; MLCK1; MYLK1; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; Kinase-related protein; KRP; Telokin
分子量： 211kD
信号通路： Calcium;Vascular smooth muscle contraction;Focal adhesion;Regulates Actin and Cytoskeleton;
功能： alternative products:Additional isoforms seem to exist,catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,cofactor:Calcium.,cofactor:Magnesium.,enzyme regulation:Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these tyrosine residues are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation.,function:Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.,online information:Myosin light-chain kinase entry,PTM:MLCK is probably down-regulated by phosphorylation.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 Ig-like C2-type (immunoglobulin-like) domains.,subunit:All isoforms including Telokin bind calmodulin.,tissue specificity:Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell projection, lamellipodium . Cleavage furrow . Cytoplasm, cytoskeleton, stress fiber . Localized to stress fibers during interphase and to the cleavage furrow during mitosis. .
组织表达： Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF).
科研货号： PLP001111

MYLK (phospho Tyr464) Polyclonal Antibody

Catalog No PLP001111

Product information

基因名称： MYLK
蛋白名称： Myosin light chain kinase smooth muscle
Human_gene_id： 4638
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4638
Human_swiss_prot_no： Q15746
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15746/entry
Mouse_swiss_prot_no： Q6PDN3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6PDN3
特异性： Phospho-MYLK (Y464) Polyclonal Antibody detects endogenous levels of MYLK protein only when phosphorylated at Y464.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MYLK; MLCK; MLCK1; MYLK1; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; Kinase-related protein; KRP; Telokin
分子量： 211kD
信号通路： Calcium;Vascular smooth muscle contraction;Focal adhesion;Regulates Actin and Cytoskeleton;
功能： alternative products:Additional isoforms seem to exist,catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,cofactor:Calcium.,cofactor:Magnesium.,enzyme regulation:Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these tyrosine residues are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation.,function:Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.,online information:Myosin light-chain kinase entry,PTM:MLCK is probably down-regulated by phosphorylation.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 Ig-like C2-type (immunoglobulin-like) domains.,subunit:All isoforms including Telokin bind calmodulin.,tissue specificity:Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell projection, lamellipodium . Cleavage furrow . Cytoplasm, cytoskeleton, stress fiber . Localized to stress fibers during interphase and to the cleavage furrow during mitosis. .
组织表达： Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF).
科研货号： PLP001111

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