ACAP1 (phospho Ser554) Polyclonal Antibody

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商品货号： PLP001009

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ACAP1
蛋白名称： Arf-GAP with coiled-coil ANK repeat and PH domain-containing protein 1
Human_gene_id： 9744
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9744
Human_swiss_prot_no： Q15027
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15027/entry
Mouse_swiss_prot_no： Q8K2H4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K2H4
特异性： Phospho-ACAP1 (S554) Polyclonal Antibody detects endogenous levels of ACAP1 protein only when phosphorylated at S554.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000-40000. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
分子量： 82kD
信号通路： Endocytosis;
功能： domain:PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.,enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.,function:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.,miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.,PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 1 BAR domain.,similarity:Contains 1 PH domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.,tissue specificity:Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
组织表达： Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
科研货号： PLP001009

ACAP1 (phospho Ser554) Polyclonal Antibody

Catalog No PLP001009

Product information

基因名称： ACAP1
蛋白名称： Arf-GAP with coiled-coil ANK repeat and PH domain-containing protein 1
Human_gene_id： 9744
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9744
Human_swiss_prot_no： Q15027
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15027/entry
Mouse_swiss_prot_no： Q8K2H4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K2H4
特异性： Phospho-ACAP1 (S554) Polyclonal Antibody detects endogenous levels of ACAP1 protein only when phosphorylated at S554.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000-40000. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
分子量： 82kD
信号通路： Endocytosis;
功能： domain:PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.,enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.,function:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.,miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.,PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 1 BAR domain.,similarity:Contains 1 PH domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.,tissue specificity:Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
组织表达： Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
科研货号： PLP001009

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