Raf-B (phospho Thr599) Polyclonal Antibody

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商品货号： PLP000973

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： BRAF
蛋白名称： Serine/threonine-protein kinase B-raf
Human_gene_id： 673
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=673
Human_swiss_prot_no： P15056
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15056/entry
Mouse_gene_id： 109880
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109880
Mouse_swiss_prot_no： P28028
Mouse_swiss_link： http://www.uniprot.org/uniprot/P28028
特异性： Phospho-Raf-B (T599) Polyclonal Antibody detects endogenous levels of Raf-B protein only when phosphorylated at T599.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 ,IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
分子量： 84kD
信号通路： Regulation of Actin Dynamics; MAPK_ERK_Growth;MAPK_G_Protein; Cell Growth; mTOR
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 zinc ions per subunit.,disease:Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,disease:Defects in BRAF are involved in a wide range of cancers.,disease:Defects in BRAF are involved in lung cancer [MIM:211980].,disease:Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RBD (Ras-binding) domain.,subunit:Interacts with RIT1.,tissue specificity:Brain and testis.,
相关产品： YT3988,YT3987,YT3986,YT3985,YT3984,YP0979,YP0780,YP0716,YP0461,KA3050C,KA3049C,KA1742C,KA1697C,KA1035C
细胞定位： Nucleus . Cytoplasm . Cell membrane . Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. .
组织表达： Brain and testis.
tag： hot
科研货号： PLP000973

Raf-B (phospho Thr599) Polyclonal Antibody

Catalog No PLP000973

Product information

基因名称： BRAF
蛋白名称： Serine/threonine-protein kinase B-raf
Human_gene_id： 673
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=673
Human_swiss_prot_no： P15056
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15056/entry
Mouse_gene_id： 109880
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109880
Mouse_swiss_prot_no： P28028
Mouse_swiss_link： http://www.uniprot.org/uniprot/P28028
特异性： Phospho-Raf-B (T599) Polyclonal Antibody detects endogenous levels of Raf-B protein only when phosphorylated at T599.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 ,IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
分子量： 84kD
信号通路： Regulation of Actin Dynamics; MAPK_ERK_Growth;MAPK_G_Protein; Cell Growth; mTOR
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 zinc ions per subunit.,disease:Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,disease:Defects in BRAF are involved in a wide range of cancers.,disease:Defects in BRAF are involved in lung cancer [MIM:211980].,disease:Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RBD (Ras-binding) domain.,subunit:Interacts with RIT1.,tissue specificity:Brain and testis.,
相关产品： YT3988,YT3987,YT3986,YT3985,YT3984,YP0979,YP0780,YP0716,YP0461,KA3050C,KA3049C,KA1742C,KA1697C,KA1035C
细胞定位： Nucleus . Cytoplasm . Cell membrane . Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. .
组织表达： Brain and testis.
tag： hot
科研货号： PLP000973

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