AQP2 (phospho Ser256) Polyclonal Antibody

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商品货号： PLP000972

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： AQP2
蛋白名称： Aquaporin-2
Human_gene_id： 359
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=359
Human_swiss_prot_no： P41181
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41181/entry
Mouse_gene_id： 11827
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11827
Mouse_swiss_prot_no： P56402
Mouse_swiss_link： http://www.uniprot.org/uniprot/P56402
Rat_gene_id： 25386
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25386
Rat_swiss_prot_no： P34080
Rat_swiss_link： http://www.uniprot.org/uniprot/P34080
特异性： Phospho-AQP2 (S256) Polyclonal Antibody detects endogenous levels of AQP2 protein only when phosphorylated at S256.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
分子量： 29kD
功能： disease:Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.,domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.,online information:AQP2 pages,PTM:Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,subcellular location:Shuttles from vesicles to the apical membrane.,tissue specificity:Expressed in renal collecting tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity). .
组织表达： Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718).
科研货号： PLP000972

AQP2 (phospho Ser256) Polyclonal Antibody

Catalog No PLP000972

Product information

基因名称： AQP2
蛋白名称： Aquaporin-2
Human_gene_id： 359
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=359
Human_swiss_prot_no： P41181
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41181/entry
Mouse_gene_id： 11827
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11827
Mouse_swiss_prot_no： P56402
Mouse_swiss_link： http://www.uniprot.org/uniprot/P56402
Rat_gene_id： 25386
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25386
Rat_swiss_prot_no： P34080
Rat_swiss_link： http://www.uniprot.org/uniprot/P34080
特异性： Phospho-AQP2 (S256) Polyclonal Antibody detects endogenous levels of AQP2 protein only when phosphorylated at S256.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
分子量： 29kD
功能： disease:Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.,domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.,online information:AQP2 pages,PTM:Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,subcellular location:Shuttles from vesicles to the apical membrane.,tissue specificity:Expressed in renal collecting tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity). .
组织表达： Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718).
科研货号： PLP000972

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