DRP1 (phospho Ser637) Polyclonal Antibody

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商品货号： PLP000836

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： DNM1L
蛋白名称： Dynamin-1-like protein
Human_gene_id： 10059
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10059
Human_swiss_prot_no： O00429
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00429/entry
Mouse_gene_id： 74006
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74006
Mouse_swiss_prot_no： Q8K1M6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K1M6
Rat_gene_id： 114114
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114114
Rat_swiss_prot_no： O35303
Rat_swiss_link： http://www.uniprot.org/uniprot/O35303
特异性： Phospho-DRP1 (S637) Polyclonal Antibody detects endogenous levels of DRP1 protein only when phosphorylated at S637(human), S643(mouse), S656(rat), .
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela
实测条带： 81kD
信号通路： Endocytosis;Fc gamma R-mediated phagocytosis;
功能： catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Functions in mitochondrial and peroxisomal division probably by regulating membrane fission. Enzyme hydrolyzing GTP that oligomerizes to form ring-like structures and is able to remodel membranes. May also play a role on organelles of the secretory pathway.,miscellaneous:Isoform 1 and isoform 2 inhibits peroxisomal division when overexpressed while isoform 3 and isoform 4 have no effect.,PTM:Phosphorylated by GSK3B.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,subcellular location:Mainly cytosolic. Also membrane-associated. Localizes to mitochondria at spots of division events. Associated with peroxisomal membranes, it is recruited in part by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear.,subunit:Homotetramer; N-terminal part binds to the C-terminal part of another DNM1L. Can self-assemble in multimeric ring-like structures. Interacts with FIS1 (By similarity). Interacts with GSK3B.,tissue specificity:Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific while isoform 3 and isoform 4 are predominantly expressed in testis and skeletal muscles respectively. Isoform 2 is weakly expressed in brain, heart and kidney and isoform 5 is dominantly expressed in liver, heart and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane ; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Mainly cytosolic. Recruited by RALA and RALBP1 to mitochondrion during mitosis (PubMed:21822277). Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Mitochondrial recruitment is inhibited by C11orf65/MFI (By similarity). Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Binds to phospholipid membranes (By similarity). .
组织表达： Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons.
科研货号： PLP000836

DRP1 (phospho Ser637) Polyclonal Antibody

Catalog No PLP000836

Product information

基因名称： DNM1L
蛋白名称： Dynamin-1-like protein
Human_gene_id： 10059
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10059
Human_swiss_prot_no： O00429
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00429/entry
Mouse_gene_id： 74006
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74006
Mouse_swiss_prot_no： Q8K1M6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K1M6
Rat_gene_id： 114114
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114114
Rat_swiss_prot_no： O35303
Rat_swiss_link： http://www.uniprot.org/uniprot/O35303
特异性： Phospho-DRP1 (S637) Polyclonal Antibody detects endogenous levels of DRP1 protein only when phosphorylated at S637(human), S643(mouse), S656(rat), .
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela
实测条带： 81kD
信号通路： Endocytosis;Fc gamma R-mediated phagocytosis;
功能： catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Functions in mitochondrial and peroxisomal division probably by regulating membrane fission. Enzyme hydrolyzing GTP that oligomerizes to form ring-like structures and is able to remodel membranes. May also play a role on organelles of the secretory pathway.,miscellaneous:Isoform 1 and isoform 2 inhibits peroxisomal division when overexpressed while isoform 3 and isoform 4 have no effect.,PTM:Phosphorylated by GSK3B.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,subcellular location:Mainly cytosolic. Also membrane-associated. Localizes to mitochondria at spots of division events. Associated with peroxisomal membranes, it is recruited in part by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear.,subunit:Homotetramer; N-terminal part binds to the C-terminal part of another DNM1L. Can self-assemble in multimeric ring-like structures. Interacts with FIS1 (By similarity). Interacts with GSK3B.,tissue specificity:Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific while isoform 3 and isoform 4 are predominantly expressed in testis and skeletal muscles respectively. Isoform 2 is weakly expressed in brain, heart and kidney and isoform 5 is dominantly expressed in liver, heart and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane ; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Mainly cytosolic. Recruited by RALA and RALBP1 to mitochondrion during mitosis (PubMed:21822277). Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Mitochondrial recruitment is inhibited by C11orf65/MFI (By similarity). Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Binds to phospholipid membranes (By similarity). .
组织表达： Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons.
科研货号： PLP000836

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