MDMX (phospho Ser367) Polyclonal Antibody

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商品货号： PLP000816

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MDM4
蛋白名称： Protein Mdm4
Human_gene_id： 4194
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4194
Human_swiss_prot_no： O15151
Human_swiss_link： http://www.uniprot.org/uniprotkb/O15151/entry
Mouse_gene_id： 17248
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17248
Mouse_swiss_prot_no： O35618
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35618
Rat_gene_id： 304798
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304798
Rat_swiss_prot_no： Q5XIN1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5XIN1
特异性： Phospho-MDMX (S367) Polyclonal Antibody detects endogenous levels of MDMX protein only when phosphorylated at S367.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
实测条带： 80kD
信号通路： p53;
功能： alternative products:Additional isoforms seem to exist,domain:Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.,function:Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.,mass spectrometry: PubMed:11840567,similarity:Belongs to the MDM2/MDM4 family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SWIB domain.,subunit:Binds to p53, p73 and MDM2.,tissue specificity:In all tissues tested, with high levels in thymus.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Expressed in all tissues tested with high levels in thymus.
科研货号： PLP000816

MDMX (phospho Ser367) Polyclonal Antibody

Catalog No PLP000816

Product information

基因名称： MDM4
蛋白名称： Protein Mdm4
Human_gene_id： 4194
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4194
Human_swiss_prot_no： O15151
Human_swiss_link： http://www.uniprot.org/uniprotkb/O15151/entry
Mouse_gene_id： 17248
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17248
Mouse_swiss_prot_no： O35618
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35618
Rat_gene_id： 304798
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304798
Rat_swiss_prot_no： Q5XIN1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5XIN1
特异性： Phospho-MDMX (S367) Polyclonal Antibody detects endogenous levels of MDMX protein only when phosphorylated at S367.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
实测条带： 80kD
信号通路： p53;
功能： alternative products:Additional isoforms seem to exist,domain:Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.,function:Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.,mass spectrometry: PubMed:11840567,similarity:Belongs to the MDM2/MDM4 family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SWIB domain.,subunit:Binds to p53, p73 and MDM2.,tissue specificity:In all tissues tested, with high levels in thymus.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Expressed in all tissues tested with high levels in thymus.
科研货号： PLP000816

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