Pin1 (phospho Ser16) Polyclonal Antibody

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商品货号： PLP000697

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PIN1
蛋白名称： Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Human_gene_id： 5300
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5300
Human_swiss_prot_no： Q13526
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13526/entry
Mouse_gene_id： 23988
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23988
Mouse_swiss_prot_no： Q9QUR7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QUR7
特异性： Phospho-Pin1 (S16) Polyclonal Antibody detects endogenous levels of Pin1 protein only when phosphorylated at S16.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PIN1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1
实测条带： 18kD
信号通路： RIG-I-like receptor;
功能： catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,domain:The WW domain is required for the interaction with STIL and MPHOSPH1.,function:Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 PpiC domain.,similarity:Contains 1 WW domain.,subunit:Interacts with STIL (By similarity). Interacts with MPHOSPH1.,
相关产品： YT3730,YP0702,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus speckle . Cytoplasm . Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). .
组织表达： Expressed in immune cells in the lung (at protein level) (PubMed:29686383). The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.
科研货号： PLP000697

Pin1 (phospho Ser16) Polyclonal Antibody

Catalog No PLP000697

Product information

基因名称： PIN1
蛋白名称： Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Human_gene_id： 5300
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5300
Human_swiss_prot_no： Q13526
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13526/entry
Mouse_gene_id： 23988
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23988
Mouse_swiss_prot_no： Q9QUR7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QUR7
特异性： Phospho-Pin1 (S16) Polyclonal Antibody detects endogenous levels of Pin1 protein only when phosphorylated at S16.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PIN1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1
实测条带： 18kD
信号通路： RIG-I-like receptor;
功能： catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,domain:The WW domain is required for the interaction with STIL and MPHOSPH1.,function:Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 PpiC domain.,similarity:Contains 1 WW domain.,subunit:Interacts with STIL (By similarity). Interacts with MPHOSPH1.,
相关产品： YT3730,YP0702,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus speckle . Cytoplasm . Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). .
组织表达： Expressed in immune cells in the lung (at protein level) (PubMed:29686383). The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.
科研货号： PLP000697

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