ALK (phospho Tyr1507) Polyclonal Antibody

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商品货号： PLP000680

适应性： 人,小鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ALK
蛋白名称： ALK tyrosine kinase receptor
Human_gene_id： 238
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=238
Human_swiss_prot_no： Q9UM73
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UM73/entry
Mouse_gene_id： 11682
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11682
Mouse_swiss_prot_no： P97793
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97793
特异性： Phospho-ALK (Y1507) Polyclonal Antibody detects endogenous levels of ALK protein only when phosphorylated at Y1507.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD antigen CD246
实测条带： 150-240kD
功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.,disease:A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.,disease:A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.,function:Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 MAM domains.,subunit:Homodimer. When bound to ligand.,tissue specificity:Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .
组织表达： Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
科研货号： PLP000680

ALK (phospho Tyr1507) Polyclonal Antibody

Catalog No PLP000680

Product information

基因名称： ALK
蛋白名称： ALK tyrosine kinase receptor
Human_gene_id： 238
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=238
Human_swiss_prot_no： Q9UM73
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UM73/entry
Mouse_gene_id： 11682
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11682
Mouse_swiss_prot_no： P97793
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97793
特异性： Phospho-ALK (Y1507) Polyclonal Antibody detects endogenous levels of ALK protein only when phosphorylated at Y1507.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD antigen CD246
实测条带： 150-240kD
功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.,disease:A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.,disease:A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.,function:Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 MAM domains.,subunit:Homodimer. When bound to ligand.,tissue specificity:Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .
组织表达： Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
科研货号： PLP000680

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