WASP (phospho Tyr290) Polyclonal Antibody

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商品货号： PLP000674

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： WAS
蛋白名称： Wiskott-Aldrich syndrome protein
Human_gene_id： 7454
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7454
Human_swiss_prot_no： P42768
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42768/entry
Mouse_gene_id： 22376
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22376
Mouse_swiss_prot_no： P70315
Mouse_swiss_link： http://www.uniprot.org/uniprot/P70315
特异性： Phospho-WASP (Y290) Polyclonal Antibody detects endogenous levels of WASP protein only when phosphorylated at Y290.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： WAS; IMD2; Wiskott-Aldrich syndrome protein; WASp
实测条带： 60kD
信号通路： Chemokine;Adherens_Junction;Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;Pathogenic Escherichia coli infection;
功能： disease:Defects in WAS are a cause of X-linked severe congenital neutropenia (XLN) [MIM:300299]. XLN is an X-linked immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia.,disease:Defects in WAS are the cause of thrombocytopenia type 1 (THC1) [MIM:313900]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,disease:Defects in WAS are the cause of Wiskott-Aldrich syndrome (WAS) [MIM:301000]; also known as eczema-thrombocytopenia-immunodeficiency syndrome. WAS is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.,domain:The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation.,domain:The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand.,function:Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function.,online information:WAS mutation db,online information:Wiskott-Aldrich syndrome protein entry,similarity:Contains 1 CRIB domain.,similarity:Contains 1 WH1 domain.,similarity:Contains 1 WH2 domain.,subunit:Binds to CDC42, RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma. Binds the Arp2/3 complex.,tissue specificity:Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.,
相关产品： YT4896,YP0679,KA4322C,KA1348C
细胞定位： Cytoplasm, cytoskeleton . Nucleus .
组织表达： Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
科研货号： PLP000674

WASP (phospho Tyr290) Polyclonal Antibody

Catalog No PLP000674

Product information

基因名称： WAS
蛋白名称： Wiskott-Aldrich syndrome protein
Human_gene_id： 7454
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7454
Human_swiss_prot_no： P42768
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42768/entry
Mouse_gene_id： 22376
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22376
Mouse_swiss_prot_no： P70315
Mouse_swiss_link： http://www.uniprot.org/uniprot/P70315
特异性： Phospho-WASP (Y290) Polyclonal Antibody detects endogenous levels of WASP protein only when phosphorylated at Y290.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： WAS; IMD2; Wiskott-Aldrich syndrome protein; WASp
实测条带： 60kD
信号通路： Chemokine;Adherens_Junction;Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;Pathogenic Escherichia coli infection;
功能： disease:Defects in WAS are a cause of X-linked severe congenital neutropenia (XLN) [MIM:300299]. XLN is an X-linked immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia.,disease:Defects in WAS are the cause of thrombocytopenia type 1 (THC1) [MIM:313900]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,disease:Defects in WAS are the cause of Wiskott-Aldrich syndrome (WAS) [MIM:301000]; also known as eczema-thrombocytopenia-immunodeficiency syndrome. WAS is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.,domain:The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation.,domain:The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand.,function:Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function.,online information:WAS mutation db,online information:Wiskott-Aldrich syndrome protein entry,similarity:Contains 1 CRIB domain.,similarity:Contains 1 WH1 domain.,similarity:Contains 1 WH2 domain.,subunit:Binds to CDC42, RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma. Binds the Arp2/3 complex.,tissue specificity:Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.,
相关产品： YT4896,YP0679,KA4322C,KA1348C
细胞定位： Cytoplasm, cytoskeleton . Nucleus .
组织表达： Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
科研货号： PLP000674

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