CaSR (phospho Thr888) Polyclonal Antibody

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商品货号： PLP000536

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CASR
蛋白名称： Extracellular calcium-sensing receptor
Human_gene_id： 846
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=846
Human_swiss_prot_no： P41180
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41180/entry
Mouse_gene_id： 12374
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12374
Mouse_swiss_prot_no： Q9QY96
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QY96
Rat_gene_id： 24247
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24247
Rat_swiss_prot_no： P48442
Rat_swiss_link： http://www.uniprot.org/uniprot/P48442
特异性： Phospho-CaSR (T888) Polyclonal Antibody detects endogenous levels of CaSR protein only when phosphorylated at T888.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CASR; GPRC2A; PCAR1; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor; PCaR1
实测条带： 140kD
功能： disease:Defects in CASR are the cause of autosomal dominant hypoparathyroidism (FIH) [MIM:146200]. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.,disease:Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]; in which the receptor has reduced activity. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels.,disease:Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]; in which the receptor has reduced activity. NSHPT is a rare autosomal recessive life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH.,function:Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.,PTM:N-glycosylated.,PTM:Ubiquitinated by RNF19A; which induces proteasomal degradation.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with VCP and RNF19A.,tissue specificity:Found in kidney, but not in brain, lung, liver, heart, skeletal muscle, or placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein .
组织表达： Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
科研货号： PLP000536

CaSR (phospho Thr888) Polyclonal Antibody

Catalog No PLP000536

Product information

基因名称： CASR
蛋白名称： Extracellular calcium-sensing receptor
Human_gene_id： 846
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=846
Human_swiss_prot_no： P41180
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41180/entry
Mouse_gene_id： 12374
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12374
Mouse_swiss_prot_no： Q9QY96
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QY96
Rat_gene_id： 24247
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24247
Rat_swiss_prot_no： P48442
Rat_swiss_link： http://www.uniprot.org/uniprot/P48442
特异性： Phospho-CaSR (T888) Polyclonal Antibody detects endogenous levels of CaSR protein only when phosphorylated at T888.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CASR; GPRC2A; PCAR1; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor; PCaR1
实测条带： 140kD
功能： disease:Defects in CASR are the cause of autosomal dominant hypoparathyroidism (FIH) [MIM:146200]. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.,disease:Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]; in which the receptor has reduced activity. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels.,disease:Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]; in which the receptor has reduced activity. NSHPT is a rare autosomal recessive life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH.,function:Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.,PTM:N-glycosylated.,PTM:Ubiquitinated by RNF19A; which induces proteasomal degradation.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with VCP and RNF19A.,tissue specificity:Found in kidney, but not in brain, lung, liver, heart, skeletal muscle, or placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein .
组织表达： Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
科研货号： PLP000536

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