Eps15 (phospho Tyr849) Polyclonal Antibody

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商品货号： PLP000466

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： EPS15
蛋白名称： Epidermal growth factor receptor substrate 15
Human_gene_id： 2060
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2060
Human_swiss_prot_no： P42566
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42566/entry
Mouse_gene_id： 13858
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13858
Mouse_swiss_prot_no： P42567
Mouse_swiss_link： http://www.uniprot.org/uniprot/P42567
特异性： Phospho-Eps15 (Y849) Polyclonal Antibody detects endogenous levels of Eps15 protein only when phosphorylated at Y849.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p
实测条带： 100kD
信号通路： Endocytosis;
功能： disease:A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.,domain:The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.,function:Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits.,PTM:Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,similarity:Contains 3 EH domains.,subcellular location:Colocalizes with HGS on bilayered clathrin coats on endosomes.,subcellular location:Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.,subunit:Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2 and AP2B1. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP.,tissue specificity:Ubiquitously expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. .; [Isoform 2]: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with HGS on bilayered clathrin coats on endosomes.
组织表达： Ubiquitously expressed.
科研货号： PLP000466

Eps15 (phospho Tyr849) Polyclonal Antibody

Catalog No PLP000466

Product information

基因名称： EPS15
蛋白名称： Epidermal growth factor receptor substrate 15
Human_gene_id： 2060
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2060
Human_swiss_prot_no： P42566
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42566/entry
Mouse_gene_id： 13858
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13858
Mouse_swiss_prot_no： P42567
Mouse_swiss_link： http://www.uniprot.org/uniprot/P42567
特异性： Phospho-Eps15 (Y849) Polyclonal Antibody detects endogenous levels of Eps15 protein only when phosphorylated at Y849.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p
实测条带： 100kD
信号通路： Endocytosis;
功能： disease:A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.,domain:The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.,function:Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits.,PTM:Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,similarity:Contains 3 EH domains.,subcellular location:Colocalizes with HGS on bilayered clathrin coats on endosomes.,subcellular location:Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.,subunit:Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2 and AP2B1. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP.,tissue specificity:Ubiquitously expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. .; [Isoform 2]: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with HGS on bilayered clathrin coats on endosomes.
组织表达： Ubiquitously expressed.
科研货号： PLP000466

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