Tak1 (phospho Thr187) Polyclonal Antibody

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商品货号： PLP000421

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MAP3K7
蛋白名称： Mitogen-activated protein kinase kinase kinase 7
Human_gene_id： 6885
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6885
Human_swiss_prot_no： O43318
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43318/entry
Mouse_gene_id： 26409
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26409
Mouse_swiss_prot_no： Q62073
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q62073
Rat_gene_id： 1.00911e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100910771
Rat_swiss_prot_no： P0C8E4
Rat_swiss_link： http://www.uniprot.org/uniprot/P0C8E4
特异性： Phospho-Tak1 (T187) Polyclonal Antibody detects endogenous levels of Tak1 protein only when phosphorylated at T187.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1
实测条带： 77kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;WNT;WNT-T CELLAdherens_Junction;Toll_Like;NOD-like receptor;RIG-I-like receptor;T_Cell_Receptor;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity.,
相关产品： YT4537,YT4536,YT4535,YP0787,YP0424,YP0378,KA4166C,KA1706C,KA1705C,KA1508C
细胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
组织表达： Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
tag： hot
科研货号： PLP000421

Tak1 (phospho Thr187) Polyclonal Antibody

Catalog No PLP000421

Product information

基因名称： MAP3K7
蛋白名称： Mitogen-activated protein kinase kinase kinase 7
Human_gene_id： 6885
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6885
Human_swiss_prot_no： O43318
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43318/entry
Mouse_gene_id： 26409
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26409
Mouse_swiss_prot_no： Q62073
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q62073
Rat_gene_id： 1.00911e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100910771
Rat_swiss_prot_no： P0C8E4
Rat_swiss_link： http://www.uniprot.org/uniprot/P0C8E4
特异性： Phospho-Tak1 (T187) Polyclonal Antibody detects endogenous levels of Tak1 protein only when phosphorylated at T187.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1
实测条带： 77kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;WNT;WNT-T CELLAdherens_Junction;Toll_Like;NOD-like receptor;RIG-I-like receptor;T_Cell_Receptor;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity.,
相关产品： YT4537,YT4536,YT4535,YP0787,YP0424,YP0378,KA4166C,KA1706C,KA1705C,KA1508C
细胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
组织表达： Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
tag： hot
科研货号： PLP000421

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