WRN (phospho Ser1141) Polyclonal Antibody

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商品货号： PLP000398

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： WRN
蛋白名称： Werner syndrome ATP-dependent helicase
Human_gene_id： 7486
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7486
Human_swiss_prot_no： Q14191
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q14191/entry
Mouse_swiss_prot_no： O09053
Mouse_swiss_link： http://www.uniprot.org/uniprot/O09053
特异性： Phospho-WRN (S1141) Polyclonal Antibody detects endogenous levels of WRN protein only when phosphorylated at S1141.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： WRN; RECQ3; RECQL2; Werner syndrome ATP-dependent helicase; DNA helicase; RecQ-like type 3; RecQ3; Exonuclease WRN; RecQ protein-like 2
实测条带： 162kD
信号通路： Protein_Acetylation
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
组织表达： Spleen,
tag： hot
科研货号： PLP000398

WRN (phospho Ser1141) Polyclonal Antibody

Catalog No PLP000398

Product information

基因名称： WRN
蛋白名称： Werner syndrome ATP-dependent helicase
Human_gene_id： 7486
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7486
Human_swiss_prot_no： Q14191
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q14191/entry
Mouse_swiss_prot_no： O09053
Mouse_swiss_link： http://www.uniprot.org/uniprot/O09053
特异性： Phospho-WRN (S1141) Polyclonal Antibody detects endogenous levels of WRN protein only when phosphorylated at S1141.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： WRN; RECQ3; RECQL2; Werner syndrome ATP-dependent helicase; DNA helicase; RecQ-like type 3; RecQ3; Exonuclease WRN; RecQ protein-like 2
实测条带： 162kD
信号通路： Protein_Acetylation
功能： disease:Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.,disease:Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.,online information:WRN mutation db (Warner disease),PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 HRDC domain.,subunit:Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
组织表达： Spleen,
tag： hot
科研货号： PLP000398

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