TRF1 (phospho Ser219) Polyclonal Antibody

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商品货号： PLP000397

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： TERF1
蛋白名称： Telomeric repeat-binding factor 1
Human_gene_id： 7013
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7013
Human_swiss_prot_no： P54274
Human_swiss_link： http://www.uniprot.org/uniprotkb/P54274/entry
Mouse_gene_id： 21749
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21749
Mouse_swiss_prot_no： P70371
Mouse_swiss_link： http://www.uniprot.org/uniprot/P70371
特异性： Phospho-TRF1 (S219) Polyclonal Antibody detects endogenous levels of TRF1 protein only when phosphorylated at S219.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TERF1; PIN2; TRBF1; TRF; TRF1; Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
实测条带： 55kD
功能： domain:The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.,function:Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,induction:Pin2 expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis.,PTM:ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.,PTM:Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.,similarity:Contains 1 HTH myb-type DNA-binding domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.,subunit:Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1.,tissue specificity:Highly expressed and ubiquitous. Isoform Pin2 predominates.,
相关产品： YT4733,YP0400,KA1536C,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
组织表达： Highly expressed and ubiquitous. Isoform Pin2 predominates.
科研货号： PLP000397

TRF1 (phospho Ser219) Polyclonal Antibody

Catalog No PLP000397

Product information

基因名称： TERF1
蛋白名称： Telomeric repeat-binding factor 1
Human_gene_id： 7013
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7013
Human_swiss_prot_no： P54274
Human_swiss_link： http://www.uniprot.org/uniprotkb/P54274/entry
Mouse_gene_id： 21749
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21749
Mouse_swiss_prot_no： P70371
Mouse_swiss_link： http://www.uniprot.org/uniprot/P70371
特异性： Phospho-TRF1 (S219) Polyclonal Antibody detects endogenous levels of TRF1 protein only when phosphorylated at S219.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TERF1; PIN2; TRBF1; TRF; TRF1; Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
实测条带： 55kD
功能： domain:The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.,function:Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,induction:Pin2 expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis.,PTM:ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.,PTM:Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.,similarity:Contains 1 HTH myb-type DNA-binding domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.,subunit:Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1.,tissue specificity:Highly expressed and ubiquitous. Isoform Pin2 predominates.,
相关产品： YT4733,YP0400,KA1536C,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
组织表达： Highly expressed and ubiquitous. Isoform Pin2 predominates.
科研货号： PLP000397

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