LEF-1 (phospho Ser42) Polyclonal Antibody

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商品货号： PLP000371

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： LEF1
蛋白名称： Lymphoid enhancer-binding factor 1
Human_gene_id： 51176
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51176
Human_swiss_prot_no： Q9UJU2
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UJU2/entry
Mouse_gene_id： 16842
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16842
Mouse_swiss_prot_no： P27782
Mouse_swiss_link： http://www.uniprot.org/uniprot/P27782
Rat_gene_id： 161452
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=161452
Rat_swiss_prot_no： Q9QXN1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9QXN1
特异性： Phospho-LEF-1 (S42) Polyclonal Antibody detects endogenous levels of LEF-1 protein only when phosphorylated at S42.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LEF1; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha
实测条带： 55kD
信号通路： WNT;WNT-T CELLAdherens_Junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能： alternative products:Additional isoforms seem to exist,domain:Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.,function:Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.,similarity:Belongs to the TCF/LEF family.,similarity:Contains 1 HMG box DNA-binding domain.,subcellular location:Found in nuclear bodies upon PIASG binding.,subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC.,tissue specificity:Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Found in nuclear bodies upon PIASG binding. .
组织表达： Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
科研货号： PLP000371

LEF-1 (phospho Ser42) Polyclonal Antibody

Catalog No PLP000371

Product information

基因名称： LEF1
蛋白名称： Lymphoid enhancer-binding factor 1
Human_gene_id： 51176
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51176
Human_swiss_prot_no： Q9UJU2
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UJU2/entry
Mouse_gene_id： 16842
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16842
Mouse_swiss_prot_no： P27782
Mouse_swiss_link： http://www.uniprot.org/uniprot/P27782
Rat_gene_id： 161452
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=161452
Rat_swiss_prot_no： Q9QXN1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9QXN1
特异性： Phospho-LEF-1 (S42) Polyclonal Antibody detects endogenous levels of LEF-1 protein only when phosphorylated at S42.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LEF1; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha
实测条带： 55kD
信号通路： WNT;WNT-T CELLAdherens_Junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能： alternative products:Additional isoforms seem to exist,domain:Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.,function:Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.,similarity:Belongs to the TCF/LEF family.,similarity:Contains 1 HMG box DNA-binding domain.,subcellular location:Found in nuclear bodies upon PIASG binding.,subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC.,tissue specificity:Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Found in nuclear bodies upon PIASG binding. .
组织表达： Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
科研货号： PLP000371

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