Smad2/3 (phospho Thr8) Polyclonal Antibody

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商品货号： PLP000359

适应性： 人,小鼠,大鼠,猪

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SMAD2/SMAD3
蛋白名称： Mothers against decapentaplegic homolog 2/3
Human_gene_id： 4087/4088
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4087
Human_swiss_prot_no： Q15796/P84022
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15796/entry
Mouse_gene_id： 17126/17127
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17126
Rat_gene_id： 29357/25631
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29357
Rat_swiss_prot_no： O70436/P84025
Rat_swiss_link： http://www.uniprot.org/uniprot/O70436
特异性： Phospho-Smad2/3 (T8) Polyclonal Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000; IF ICC 1:100-500;ELISA 1:5000-20000
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic
实测条带： 48kD
信号通路： Regulates Angiogenesis; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; Protein_Acetylation
功能： disease:Defects in SMAD2 are found in sporadic cases of colorectal carcinoma.,function:Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.,PTM:Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo.,PTM:In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation.,PTM:Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with SMAD3 and TRIM33. Interacts with SARA (SMAD anchor for receptor activation); may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts (via PY-motif) with SMURF2. Interacts with AIP1 and HGS. Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with LBXCOR1 and CORL2.,tissue specificity:Expressed at high levels in skeletal muscle, heart and placenta.,
相关产品： YT4332,YP0362,KA1139C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
组织表达： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
tag： hot
科研货号： PLP000359

Smad2/3 (phospho Thr8) Polyclonal Antibody

Catalog No PLP000359

Product information

基因名称： SMAD2/SMAD3
蛋白名称： Mothers against decapentaplegic homolog 2/3
Human_gene_id： 4087/4088
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4087
Human_swiss_prot_no： Q15796/P84022
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15796/entry
Mouse_gene_id： 17126/17127
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17126
Rat_gene_id： 29357/25631
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29357
Rat_swiss_prot_no： O70436/P84025
Rat_swiss_link： http://www.uniprot.org/uniprot/O70436
特异性： Phospho-Smad2/3 (T8) Polyclonal Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000; IF ICC 1:100-500;ELISA 1:5000-20000
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic
实测条带： 48kD
信号通路： Regulates Angiogenesis; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; Protein_Acetylation
功能： disease:Defects in SMAD2 are found in sporadic cases of colorectal carcinoma.,function:Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.,PTM:Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo.,PTM:In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation.,PTM:Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with SMAD3 and TRIM33. Interacts with SARA (SMAD anchor for receptor activation); may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts (via PY-motif) with SMURF2. Interacts with AIP1 and HGS. Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with LBXCOR1 and CORL2.,tissue specificity:Expressed at high levels in skeletal muscle, heart and placenta.,
相关产品： YT4332,YP0362,KA1139C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
组织表达： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
tag： hot
科研货号： PLP000359

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